Ghost Hit is a unique attack type, meaning you need resistance to 'ghost hit' items to be protected from it or reduce the damage from the attack.
The attack is often significant damage which makes it quite deadly and dangerous for new characters, or characters who do not have high hit points for one reason or another.
Some monsters, such as ghosts, can only deliver a single hit with this attack type and then the creature vaporizes after damage is calculated. More powerful monsters are able to deliver ghost hit attacks as their regular attack and no risk or damage to them.
Since this is a short range or touch attack, a player with a very good Ac (Armour Class) score can use that to help avoid being a victim of this attack.